I recommend watching (and listening to) this talk by Saqib Shaikh, a blind developer using Visual Studio and how we codes and debugs with his screen reader https://www.youtube.com/watch?v=94swlF55tVc
If you want something that doesn't require any other distractions (HTML, CSS etc) then Node.js is a good choice. How about writing a RESTful API or something else self-contained? A while ago I wrote a thing which tweets train delays in a few days https://github.com/dcrichards/gordon to try out some recent Node.js features and libraries.