I'm pretty certain I've run into this a couple of times now since upgrading to Tahoe last year and had been wondering what the deal was. Had never thought to check the uptime and make note of it, but I basically never shut down my laptop.
I hope it sounds less wild if you think obesity as disease of addiction. Reducing GLP1 dose can increase the enjoyment in eating, so it makes sense why treating obesity with GLP1 is like treating alcoholism with disulfiram: Effective in theory but hard to adhere outside trials.
Type 1 diabetes (or majority of diseases) doesn't involve addiction.
We have no specific reason to believe there are concerns with GLP-1s for cancer or anything else, beyond the mildest signal in rodent studies around thyroids.
We do not have robust clinical data for things like BPC-157 but we do have strong preclinical data and an understanding of the mechanisms in play.
I use BPC-157/TB-500/Ghk-CU/KPV - so I'm certainly OK taking the risks. But those mechanisms mentioned before? The same things we're counting on for healing and inflammation reduction are the same things that we know can cause an increase in tumor growth rate and chance of metastasizing. VEGF/VEGFR2 expression are even suppression targets for some cancer therapies.
Are there powerful and useful medications out there, available today, that we both don't have good scientific data on and are free enough of serious side effects? For sure! Is everything out there that, though? No. Some things that work will have too serious of a side effect profile to be feasible. Some things won't work at all, despite however much anecdata is out there.
As for the general idea... I agree there's no law that says a medicine with a strong positive effect must also have strong side effects. And we have plenty that don't - statins, particularly the latest generation, like pitavastatin, are effectively side effect free for the hugely overwhelming majority of people and have great lipid lowering effects. Even older ones showed extremely minimal incidents of things like muscle pain - a vanishingly small number of people relative to the total amount on the medications report muscle pain, and when investigated, quite a lot of even that ends up being unrelated to the statins. Yet the narrative persists that make it sound like anyone on statins is going to have their muscles ache 24/7
But it is wildly less popular than it was and demand is well below what they built out supply to meet. Even without the tariffs the industry was going to have a major contraction and the tariffs have made it even worse.
Bardstown literally has their production line workers doing yardwork and other random tasks to keep them on payroll while not running production.
I generally agree that Americans tend to downplay the impact of Russia in WW2 but there is zero chance Russia would have won the war without the US. Even Lend-Lease going away would have resulted in a loss. Both Stalin and Kruschev agreed there.
The British Commonwealth was the biggest factor in Africa, but it's questionable how quickly they could have won out and taken the Suez without the Americans coming in late in 42, which was critical for both vital supplies like oil and also invading Italy. Japan was already getting bogged down with China and even Burma so they wouldn't have suddenly been free to do much in the European theater but just getting Italy out of the fight and forcing Germany to replace their divisions elsewhere. Italy exiting the war removed 30+ divisions between the Balkans and France, while another 70 Axis divisions were being held down by Allied forces in the Mediterranean during D-Day, with there being 33 Axis divisions in Normandy for D-Day itself. A lack of US involvement also likely means that Germany is able to hold Caucasus for longer (and take more of the oil fields), solving a sizable portion of their oil shortage issues.
With Lend-Lease but no active participation in the war from a military deployment standpoint, the UK and USSR do likely eventually win but at much greater cost and not without risk of losing. Without Lend-Lease it is highly possible that the Axis wins, at least in the European theater. Japan had kind of set themselves up to lose from the start no matter what the US did.
The best part is that Ukraine wanted to sell us their anti-drone tech to us a year ago and Trump and co didn't see fit to pursue it.
Did they not know that the Shahed-136 has seen massive fucking use in Ukraine by Russia? Did they not think that Ukraine now being able to shoot like 75%+ of them down might be an indication that, if we are planning to start some stupid pointless war with the country that makes these drones, it might be a good idea to have that same capability?
Or did they think we have an infinite ammo cheat, and we can just launch an infinite number of missiles that cost millions of dollars to shoot down a drone that costs tens of thousands?
We had literally years of intelligence on the capabilities of these drones. The admin claims "We thought it was Zelensky being Zelensky. Self promotion" - but we know how successful their anti-drone capabilities are. We have the data! YOU JUST HAD TO TALK TO THE PEOPLE TO VERIFY IT. The sheer incompetence of these people is astounding.
Literal neo-nazis have existed within the administration at relatively high levels (and likely still do, though they've gotten better about not outright bragging about it like some of those dipshits). People at even higher levels talk about conversations with literal neo-nazis, how they listen to their podcasts, etc. I'm not using this in the "I think everyone that has even remotely fascist tendencies is a neo-nazi" manner, I am using it in the "No these people are literally self described neo-nazis" manner.
The reality of the USA post WW2 is one that is full of plenty of shame. It still might be the most harmless empire there ever was, but that's a relative statement - the US has done * a lot* of harm. Perhaps a lot of good, too. Maybe even more good than harm. But almost all of that harm was unnecessary. But the past is not the future, and the present shows us marching to a darker and darker future.
Better to raise the alarm now and stop that descent rather than letting it continue.
Yes and now, go out of your bubble - and ask the immigrants streaming to the us- what do you think compared to home! And the answers is- at home they where all nazis, insane ideollougs with corrupt clans, all fanatics, buisness had no say and they hunted minorities in the streets. Thats why i left.. thats why they all leave iran, etc when they can.
They wouldn't if the us was this bad even now. Reality itself contradicts you..
The moment migration to the us stops- its finally become equally bad..
It's Tahoe specific
https://news.ycombinator.com/item?id=47670995
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