Down $13+ (about 4%) after hours, and the drop was apparently after they mentioned the search revenue miss on the earnings call because it was flat when I looked an hour ago. So not entirely priced in.
IIRC there was a search revenue miss last quarter too. Likely because of AI cannibalization of search results. Classic search is very heavily monetized, and a monopoly ad market. AI mode is currently lightly monetized, and a much more segmented market, and one that is harder to target ads for. Plus there are easily half a dozen LLM vendors now, while Search was a clear monopoly.
This is something investors should be very concerned about. It's not at all clear that whatever comes post-Gemini will be nearly as profitable as Search has been for the last 20 years.
> Internal docs: Meta earned $18B+ in annual ad sales from China in 2024, making up 10%+ of its global revenue, with $3B+ linked to fraudulent ads, like for scams
If you believe really hard and really try you can transmutate lead into manganese. Of course, eating all that lead will probably kill you first. At least your Lyme won't be a problem any more.
And all those years alchemists were wasting their time trying to change lead into gold when they could have been going for manganese to eliminate Lyme disease! Greed has no bounds
> In its metallic state it appears to be inert when swallowed, unless it meets with much acidity in the alimentary canal, or is in a state of minute division ; its compounds are, however, all of them more or less poisonous.
> Mercury has been employed in one or other of its forms in almost all diseases ; but each of its numerous preparations is supposed to have some peculiarity of action of its own, combined with that common to all the compounds of this metal. The mercurials form, indeed, one of the most important classes of the materia medica.
He goes on to explain that mercuric acetate is the basis of Keyser's antivenereal pills (according to Robiquet), that mercuric chloride (which is probably what you meant by "mercuric chlorine") is "employed as an alterative, diaphoretic, and resolvent, in the chronic forms of secondary syphilis, rheumatism, scrofula, cancer, old dropsies, numerous skin diseases, &c." He also devotes a lot of space to emphasizing how important it is to be careful of it, describing the symptoms of poisoning with it, and explaining how to analyze "animal tissue" to detect mercury salts in it. He also discusses the use of mercuric nitrate in syphilis.
But never in all the pages he devotes to the uses of mercury and its compounds does he suggest that anyone ever used metallic mercury for syphilis.
I've also never seen a suggestion that mercuric chloride was ineffective against syphilis. Wikipedia says, "Once used as a first line treatment for syphilis, it has been replaced by the more effective and less toxic procaine penicillin since at least 1948."
Less academic of course. And mercuric chlorine was an autocorrect mistake from chloride.
If mercuric chloride was actually effective (without killing the patient) seems like total luck, and generally the first actual effective treatment was considered Salvarsan [https://en.wikipedia.org/wiki/Arsphenamine] - which was arsenic based yes?
Until antibiotics came around.
But people tried all sorts of things, including liquid mercury, as your source notes.
The WebMD page is about calomel, mercuric chloride, and perchloride of mercury, not metallic mercury; the body text is clear about this, but the title is wrong. It describes all kinds of poisoning symptoms that don't occur with metallic mercury. So too for the mercury section of the Science Museum web page, except for a brief mention of attempts to treat with mercury vapors. And neither of them seems very credible.
My source did not note that people tried liquid mercury.
“Mercury has been employed in one or other of its forms in almost all diseases”
Are you really saying that in that time, no one tried the most obvious form?
You’re right though that I was wrong it was the primary one - I’m truly horrified at the various things people tried. But I guess untreated syphilis is one of the worst possible ways to die, and I’d try pretty much anything too.
I hypothesize that the appetite-suppressing effect of GLP-1 agonists contributes to the normalization of dopamine signaling in the brain. By mitigating the exaggerated dopamine fluctuations seen in food and sugar addiction, GLP-1 may promote a return to dopamine homeostasis, thereby reducing compulsive or addiction-like reward-seeking behaviors.
