Hacker Newsnew | past | comments | ask | show | jobs | submit | exact_string's commentslogin

These tests always make me wonder: What qualifies as a valid pattern rule?

For example, why wouldn't "0" be a correct answer here (rule being "every other number on the right should be 0, other numbers do not have a pattern")?


Exactly, it's completely arbitrary. I like to frame it in terms of fitting n points (the existing data in the problem) to a polynomial of degree n+1, where there's an infinite number of ways to pick a solution and still satisfy the initial data.


Maybe the "solution with the lowest Kolmogorov complexity".

In a sibling comment, I replied that usually a repeating pattern can also be applied, but that one usually requires storing the n-sequence, rarely making it the shortest encodable rule.


I think it's better phrased as "find the best rule", with a tacit understanding that people mostly agree on what makes a rule decent vs. terrible (maybe not on what makes one great) and a tacit promise that the sequence presented has at least one decent rule and does not have multiple.

A rule being "good" is largely about simplicity, which is also essentially the trick that deep learning uses to escape no-free-lunch theorems.


This is exactly what I hated about these kind of questions!!

Or just, the pattern simply repeats for the n next number.. like come on, there is no objective metric for which rule is "better".


The information you can get from light miscroscope images is quite limited though.

On the other hand, maybe it would be enough to filter out every cell that is not identified as a blood cell. This should be an easier task.

Probably we could direct only a small part of blood into this filtering machine at a time. Sounds like it would be still more like a machine detecting if there are cancer cells present in the bloodsteam rather than a machine eliminating metastasization.

I think the "cure cancer without biology" approach makes somewhat sense (I assume you would still need some biology :) ). Don't many surgeries already fall into this category? Let's say we made an automated colonoscopic machine that scanned the whole intestine and destroyed all abnormal colonic crypts. Now if this machine worked well, you would essentially cure at least those colon cancers that go through some aberrant crypt stage.


This is interesting since I remember having much lower latency for 3G, perhaps < 50 ms, about 10 years ago. :) At that time, some of my friends were even using the home 3G to play games.


Most of these historical disruptive technologies seem to affect only a relatively small group of professionals or then small part of human skills. Therefore there are not too many people complaining and also most of these people can find some new jobs, perhaps after retraining.

On the contrary, AI could affect large groups of professionals and large (if not all) part of human skills. The protests opposing AI might then be completely different scale than the previous protests.

Also the an individual losing their job would suffer more since there might be nothing they could do, even after retraining, that AI couldn't.


And I thought this would be about keeping your work laptop safe. :-)


I think the point of "But it is only electricity" means that _currently_ the situation is not as good as one might think based on electricity production.


To quote from elsewhere.

“Coal-fired power stations emit over 10 Gt of carbon dioxide each year,[4] about one fifth of world greenhouse gas emissions, so are the single largest cause of climate change”

https://en.m.wikipedia.org/wiki/Coal-fired_power_station

The counter factual; if the 60% of electricity coming form wind or sunshine at this instant was from coal, then 10 Gt of carbon dioxide each year becomes 20/30/40/50 Gt of carbon dioxide each year and global emmisions are significantly more than what they are now.

Purely hypothetical, but it is where we were.


You can use the median of medians with quickselect to guarantee the O(N) time complexity.


I assume this is yet another sequencing company outsourcing the actual sequencing?

>> Do you sell or share my data with anyone?

> No, we do not sell or share your data, including your DNA data, with anyone.

However, in their privacy policy:

> Your Personal Information may be shared in the following ways:

> With our service providers, allowing them to provide their services to us.

edit:

More clearly stated here:

https://sequencing.com/ordering-dna-test-kit-and-genome-sequ...

> When you purchase the Ultimate DNA Test or Ultimate Genome Sequencing test, your test will be processed by our Laboratory Partners. We will provide our Laboratory Partner with only your basic contact information so that it can send you a DNA collection kit; we will not share your billing information with our Laboratory Partner but will pass on your payments to them.


> However, in their privacy policy:

That does not mean they are sharing your genetic data, maybe just address phone number etc.

I had the WORST experience with Nebula Genomics which ended up with them refunding my money after waiting 6 months.

I hope this is not another one of those companies. I still have some blank spots I am trying to understand from my 23andMe results and this would be great.


I emailed Sequencing.com asking what the difference was between them and Nebula Genomics and this is what they wrote back:

(1) Nebula is our laboratory partner, and they sequence with high-throughput MGI DNBSEQ-T7 DNA sequencing machines.

(2) They are our laboratory provider, but the product is not the same! The whole genome sequencing product sold by Nebula on their site is different from the Ultimate Genome Sequencing service we offer in some key ways. One big one is that our service includes more than $200 in DNA analysis apps and reports (such as the Healthcare Pro report designed for healthcare providers and the Rare Disease Screen that analyzes thousands of rare diseases).

The biggest difference, however, is in the processing of the raw genetic data into data files that you can then use to get health insights. We have enhanced processing for these kits that is able to create insights not available from Nebula directly, including enhanced raw data processing through two special bioinformatics pipelines that provide comprehensive data and analysis of structural variations, copy number variations, and mitochondrial heteroplasmy. Both Telomere Length and HLA Typing are coming soon and will be retroactively added to all past purchases of our Ultimate Genome Sequencing service.

This is all fed into our One Genome technology, which allows you to do analysis in ways that you can't do anywhere else. This technology takes all of your genetic data and turns it into an enhanced virtual genome. This advantage of this is that you can run analysis on everything all at once, where in some other cases you might have separate files that can't be analyzed simultaneously.

The long and short of it is that it takes a lot of processing to turn raw genetic data into usable data, and then to analyze that data. That piece is where we come in, and are at the forefront of the field.


...and seems that Nebula Genomics also outsources their sequencing:

> At its discretion, Nebula may use third-party laboratories to perform DNA extraction, sequencing, and data analysis.

(https://nebulagenomics.zendesk.com/hc/en-us/articles/3600243...)

I would guess the samples are eventually sequenced by BGI although Nebula FAQ (https://nebula.org/faqs/) says they sequence in EU.


Oh my...RUN FOR THE HILLS! Seriously, search for the complaints about them on Twitter.

Thank you so much for revealing this to everyone.


I was scared off from using Nebula when they claimed to secure my data privacy by using a blockchain.


What happened with Nebula? I have been genuinely considering trying out that service and this is the first negative thing I've seen about it.


It is hard, but if you search you will find countless stories like this:

https://twitter.com/TrentBrown/status/1434246929035055105


Note FDA rules require them to retain the data for a few years.


Any idea what the reasoning behind these FDA rules is?


European here: I can't wait to use my gdpr superpowers to cause an expectation violation there.


Doesn't the GDPR have an exception for data required for legal reasons?

Anyway, an US lab won't care about it.


It has some cut outs, but not as many as you would think.

The US lab is marketing to EU customers. They will care about GDPR (heck, they even claim to be compliant on their website).


In my case the only step left was supposed to be getting the offer and compensation approved, surprise!


Ouch good luck for it, hope it works out. You've passed the committee I'm guessing?


Yup, passed the hiring committee. Also the team is happy to have me.

:'(


Don't worry, it is highly unlikely Google doesn't offer someone who has already cleared HC. If they slow down, it would most likely mean it for new candidates who still haven't finished the interview process.


I guess the problem, and the point of the parent post, is that the full containment of the omicron variant might be very difficult in the long term.

Also since the omicron is milder and vaccines rather effective (as long as you don't refuse taking one), it's worth asking how much collective good is gained by personal inconvenience.

At least some people in South Korea seem to think that in the current situation the old restrictions are not worth it: https://www.ft.com/content/4be21b01-efd3-4f67-b353-7bad9eb33...


Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: