You forgot to mention the great hand-made fudge.

The only real down-side is the focus on hard science patentable IP - which makes it a bit more difficult to get noticed if you're not in that space.

Dublin is insanely expensive, and not to put too fine a point on it, but every Irish investor will hold his breath until you get the much-required Enterprise Ireland seal of potential approval. As a place to live, Dublin is actually more expensive than either London or New York. In both London & NY you have the option to go down market. Cheaper digs, more suppliers, more options. Dublin is a small city with few options on many levels.

Also, having worked in a (very) well funded Dublin based start-up, I would add that the infrastructure isn't great.

Infrastructure? What infrastructure?

http://almacz.wordpress.com/2010/01/24/living-in-eire/

Seconded. As a native Dubliner, I am always impressed with how cheap other european cities are when I visit there.