I grew up with the understanding that acetaminophen was the safe choice for fever or aches, and ibuprofen what the more potent compound for inflammation and severe pain. I recall casual anecdotes that "my doctor said 1.5x or 2x ibuprofen dose is ok when warranted" to address major incursions.
I've never once thought about taking more than the recommended dosage of acetaminophen, largely because I had no expectation that it would provide additional benefit..
In reality, I try to consume 1/2 doses of anything or nothing at all, unless it's a serious medical treatment being administered by a professional.
> largely because I had no expectation that it would provide additional benefit..
An interesting thing with ibuprofen is that at the regular dose of 400mg it inhibits pain but if you take 1600mg it doesn't inhibit much more pain than the 400mg dose, but the inflammatory effect does increase significantly. A lot of people don't know that and take too much thinking it scales linearly.
I think most overdoses happen as a result of someone trying to hurt themselves, but I’ve also previously been in sufficient pain (always dental) that I’m counting the minutes down to when I can take more painkillers, so it’s easy to see how you could take double the expected dosage.
If your doctor recommends to take a specific dose, take the specific dose. Don't half it. Taking half of stuff can also cause further damage. Like with antibiotics, where it can lead to bacteria becoming resistant.
So don't be the "smarter" person. Do as your doctor says and if you have doubts, consult another doctor before just doing what you think is safe, but actually isn't.
Yes that's correct, but in doing so remember that only person that cares most about you and your health is YOU - doctor cares about you for 10-15min, then next patient is waiting, and the level of doctor's care is inversely proportional to the level of burnout.
Is this not the case for OTC drugs? Specifically, the two mentioned in the article. I rarely take either of them, but if my doctor tells me to take 1 ibuprofen every 6 hours or so, if I halve that am I actually doing more damage?
In general, taking a lower dose than recommended can cause problems, but aside from antibiotics, the problems are probably going to be from insufficiently treating the underlying condition, rather than the medication itself. Most OTC drugs give a single recommended dosage for all adults, so some people will necessarily get a lower "effective" dose than others (eg. a 200 lb man compared to a 90 lb woman).
> Specifically, the two mentioned in the article. [...] but if my doctor tells me to take 1 ibuprofen every 6 hours or so, if I halve that am I actually doing more damage?
With the caveat that I'm not a doctor, you should be fine: the only effect of acetaminophen is pain suppression, so if the pain is tolerable, then you should be fine. Ibuprofen has some anti-inflammatory effects that could be important here, but realistically, if the anti-inflammatory effects are the primary reason for the prescription, then your doctor is more likely to prescribe naproxen or celecoxib.
But if this ever comes up for you again, probably the best solution would be to tell your doctor/pharmacist "I have a high pain tolerance, would it be okay if I take less?", since in my experience, medical practitioners are generally pretty happy to hear when you want to take less drugs.
Check out the officially supported project Lemonade[0] by AMD. It has gfx1151 specific builds of vLLM, llama.cpp, comfy-ui, and even a PR to merge a Strix Halo port of Apple’s MLX[1] with a quick and easy install.
Qwen3.5-9B has been extremely useful for local fuzzy table extraction OCR for data that cannot be sent to the cloud.
The documents have subtly different formatting and layout due to source variance. Previously we used a large set of hierarchical heuristics to catch as many edge cases as we could anticipate.
Now with the multi-modal capabilities of these models we can leverage the language capabilities along side vision to extract structured data from a table that has 'roughly this shape' and 'this location'.
I think just putting it on the companies is enough. If the fines are serious and can put your company out of business, and are enforced, then the companies themselves will probably work out processes for not doing stupid stuff.
Whether that be creating some sort of certifications that would be prized by the companies, knowing to hire a specialized team for a security review, or anything else.
If everyone knows that messing up security gets you in real trouble and the company loses real money, and it happens all the time, and it's not just "Facebook fined $x million for doing shady stuff", then I think the industry will adapt.
Like when GDPR got released and no matter if I thought we are or are not handling PII, I had to read up and double-check my assumptions just because it was being talked about all over the place and it would be embarrassing to be caught with your pants down when you didn't actually intend to do a shady thing.
> I think just putting it on the companies is enough. If the fines are serious and can put your company out of business
They don't care. It's either never enough to make them care, or the company can just bankrupt and you go do something else.
If you or your manager has the threat of jail in the back of their mind, it's no longer just someone else's money being lost, it's personal.
> If everyone knows that messing up security gets you in real trouble and the company loses real money
There's already huge fines on paper for this, but never ever are the fines enough. It's always factored in the "cost of doing business". Also it's still someone else's money, why would an engineer care?
Please show me a GDPR fine that hit hard enough to scare companies into not fucking up? Evidently here it was not enough for Fiverr.
Edit: Just to provide an example, Takata airbags have been recalled massively (if you don't know why, look it up) but the company is now bankrupted and who is footing the bill? Their customers.
You cannot impose a fine on them, as it's bankrupt (now, but it was always the plan). They deliberately sold dangerous airbags and now what can you do so it doesn't happen again? Fine them some more? or maybe throw a few execs in jail because they knew of the problem and continued as usual.
Thats funny, it failed my usual ‘hello world’ benchmark for LLM’s:
“Write a single file web page that implements a 1 dimensional bin fitting calculator using the best fit decreasing algorithm. Allow the user to input bin size, item size, and item quantity.”
Qwen3.5, Nematron, Step 3.5, gpt-oss all passed first go..
I realize it does not address the OP security concerns, but I'm having success running rocm containers[0] on alpine linux specifically for llama.cpp. I also got vLLM to run in a rocm container, but I didn't have time to to diagnose perf problems, and llama.cpp is working well for my needs.
I've been thoroughly impressed with tmux control mode[0] in iTerm2. This lets you manage remote terminal windows with your local window management provider. It is currently in the process of being implemented in ghostty[1] as well, can't wait!
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