I posted this here in hope more people would be aware of the long term risks involved with SSRI, which are often not discussed from the doctors. These symptoms might only appear after the withdrawal.
Some manufacturers and healthcare organisations are being to label this as a potential side effect. You can find a one line warning on NHS website now.
People take the drug are usually desperate and at their most vulnerable periods in life. It’s very risky to make life-changing decisions, more so without complete knowledge.
Doctors usually won’t even listen to cases of PSSD by simply attributing the SD as remission of depression. But there’re some recent studies on how SSRI could change neutral receptors in a non-reversible way, which could be the potential mechanism.
Be aware that the said antidepressant is an SSRI, which has the potential to cause permanent sexual dysfunction (PSSD) [1]. It seems that we don’t quite understand how the drug works. Most doctors threw this condition out of the window by claiming SD is caused by depression. There have been some recent studies showing possible mechanisms behind it. Some manufacturers and healthcare organisations (NHS) are beginning to label this as a potential side effect. But in general it’s not well known.
I can tell you from personal use as someone with Bipolar Disorder, my ding-a-ling works fine before I start taking it and after the first week I have nothing but a wet noodle down there. So no, the SD is not caused by depression, it is caused by Prozac.
The mechanism of action how this helps is probably so simple that people who have over complicated thoughts cannot see the answer. Serotonin is made from tryptophan by the TPH enzyme. But Tryprtophan is also turned into kynurenine by an enzyme called IDO. This kynurenine pathway is crucial to resolving inflammation and the IDO enzyme is directly activated by inflammation.
When you take prozac so much serotonin builds up that it starts inhibiting the TPH enzyme and pushes more tryptophan down the kynurenine pathway and resolves inflammation.
Depression in probably most of the cases is an inflammatory disorder, which is why prozac helps some people with depression.
It has been shown that COVID-19 infection results in alterations of the kynurenine pathway. I will make a guess that prozac will end up helping some people but not everyone.
I see a lot people bashing on how iPadOS is holding back the hardware of the iPad Pro. I totally understand where this train of thoughts is coming from. But how many of these people actually tried to use the iPad Pro to its fullest extent as the main computer? I suspect most of the people here are accustomed to MacOS and never really dug iPadOS for productivity for extended periods of time.
Besides, the iPad Pro is really not designed nor advertised as replacement for MacBook. They have very different audiences in mind. Of course it sucks for the desktop tasks that MacOS was built for. But the iPad Pro beats the Mac for artists, students, and researchers in most tasks.
I’ve been using an iPad Pro for all of my work as a mathematical physicist for many years. I think the iPadOS is absolutely fantastic for what I do on a daily basis: editing and reading PDFs (LiquidText), writing with LaTeX (TeX Writer), opening a ton of Safari tabs. It can even do an okay job on editing videos (LumaFusion), photos (Darkroom), writing codes (Textastic, Working Copy). Of course it’s not the best for all of these things, but it excels on where the MacOS sucks, and vice versa.
As for the new iPad Pro announcement, I absolutely don’t think the M1 is a waste. I can totally see myself utilising the extra RAM to stop Safari tabs from unloading, to working on larger workspace in LiquidText, to editing more tracks in LumaFusion, and etc.
Sure physics is “stuck” in the sense that in the last 30 years it hasn’t made the progress as revolutionary as in the 30 years before that. But it’s still progressing probably as well as any other foundational subjects. What happened in the late 20th century was more of a miracle in the history of human knowledge. We couldn’t expect that to happen every few decades.
Epic is conveying that the 30% cut on App Store was raising the prices. But Xbox and PlayStation has the same cut, yet Epic has lower pricing on these platforms.
Are you sure Epic hasn't negotiated some sort of deal with Xbox and playstation to lower the cut to a more reasonable rate given their volume of transactions.
To clarify, I work in the gaming industry and I've heard rumors of large publishers negotiating better terms when they get to a certain magical number of transactions/gross rev. I'm not sure I've read any reporting on it. The sources I heard this from would have been in a position to know but, I can't really point to any hard data. I wouldn't be at all surprised if it were true. I've heard it can be as low as 10-15% but again I don't have any evidence on that.
I don't think it's realistic to assume that 30% of all Fortnite revenues on xbox/playstation is still going to the platform holders. Valve already offers a 20% cut to large-volume titles on Steam, so it's plausible that Epic would have a custom deal with the console vendors.
