amen. I've tried 3 tnf inhibitors that have not worked (and had negative side effects). Cosentyx (il 17a inhibitor) kinda scares me. I always like to keep my hopes that some better autoimmune treatments could come soon
For context, I had been on Taltz before for psoriasis, and it worked very well. It seems like il17 inhibitors specifically are extremely targeted in what they affect.
In comparison, I was also on otezla at one point (tnf-a inhibitor) and it didnt work for me either, and the side effects were terrible.
It's the few instances of new onset IBD and generally the GI side effects. I'm lucky enough to have a pretty solid GI system that I don't want to risk messing with. I get very anxious with medicine, and my ankylosing spondylitis is sufficiently slow moving on MRI and tolerable enough that I prefer not to use the medicines. I had too many strange side effects whilst on Humira/Remicade such that it scares the crap out of me.
Someone commented above, but Jonathan Haidt "the anxious generation" is a place to start for a deeper analysis on the issue. Here is part 1 of a 3 part series of posts of his. I can't speak to the correlations and study directly, but Haidt's work is probably what you're looking for. https://www.afterbabel.com/p/the-case-for-causality-part-1 (the commenter elsewhere linked part 3 which I believe directly refutes this meta analysis)
I respectfully partially disagree. Sure, the term "rescue" is a bit over the top and evokes "Apollo 13" vibes. OTOH, Boeing has "$14.8bn in Pentagon contracts in 2022" [1]. Boeing has plane crash issues for years now across more than 1 model. And its space program just had an embarrassing failure. Given their failures, the amount of revenue they get from the US federal gov, and their level of influence over various aspects of defense funding/spending, I do not think this story should be dismissed as an overly sensational, run-of-the-mill story that does not make the news.
IMO, US citizens/taxpayers would be very justified to be pissed about the failures of a company that their tax dollars heavily fund (from the same article I referenced above, its like 37% of their revenue). The series of very public failures that affect people directly (planes) and affect their tax dollars (recent series of failures of their space program) certainly warrants outrage and coverage. that's my 2 cents
Why wouldn't a congress person in this instance do the opposite? Give a show of hand for sake of TV and voters. Say they voted one way, but then vote the way they might be lobbied/influenced to? The public votes of congress people is frequently a campaign talking issue by virtue of opponents lambasting each other's vote records. How would secret ballots in congress have anything but the opposite effect of what you intend?
For what’s it’s worth, autoimmune drugs are amongst the highest grossing due to their cost. Rheumatoid arthritis, psoriasis, MS all do have a lot of study. I wouldn’t say it’s enough, but I don’t think the prevalence of me/cfs alters anything due to the high prevalence of the other diseases. Immune disorders are definitely mysterious though
Only have been on in for like 3 seconds before crashing, the game definitely gave me early RuneScape vibes. Tbt to RuneScape in the school library in like 2006
I can't imagine any jurisdiction that tried this would see anything other than large companies prohibiting their software from being used in that jurisdiction. Any company that then grew large would quickly exit. Every iOS update requires 1B+ to sit in escrow?
This is an unfair parallel, but it's like worrying about businesses who advertise on pornographic sites or on cigarette boxes. Allowing visibility to businesses who advertise on a certain platform could be judged (by society, law, and voters) to be outweighed by the need to restrict youth access to social media. There is a variety of precedent in society and law in restricting youth access to something that is otherwise deemed legal. Just because businesses advertise on social media (in my opinion), the decision to restrict access should not be altered by that advertising strategy.
