Qt programming is done in C++ or Python and it includes everything required inside the distributed app package. It's also easily skinned to look very close to native UIs (see VLC).
I've never used both of these languages and wrote only simple things in JS but I would spend a week learning Python syntax and Qt features to deliver a better UX and performance for a cross-platform app.
More like to wrap a website. I doubt that it's easier than Qt when building from scratch.