Loss of young children is considered and handled differently in different cultures though. Where it is more normal, the impact on the parent's lifes will not be as heavy.
They were from different places, but childhood mortality was common everywhere then.
My grandmother was a teenager, in 1930s Poland. My great grandmother had 3 children. All three died the same winter, from dysentery. My great grandmother was near catatonic in her depression. Later she had three more children. The youngest (my grandmother's baby brother) died of infection. These were common stories, and I was witness to that suffering even though I saw only the shade of that loss decades later. His older sister (my great aunt) is alive today, 97 years old. She still misses him.
The Grandfather was Irish. He lost a 7 year old sister to a farming accident, when he was 18. The girl was with him, and he felt that his own carelessness caused her death. I witnessed his mourning too. I even saw him cry at her grave, unusual for a man of his time and place.
Every one of those stories is a tremendous tragedy, scars on the souls of many.