The short answer is: you get used to it, but it is not ideal or a particularly healthy work lifestyle. It has many of the same problems as solitary confinement within a prison.
Since the pattern is increasing all around, more social support structures are emerging around work-from-home lifestyles, but frankly, the current state is very primitive.
There was a coworking space about half a block away from my current location, but it closed down. Unfortunately I didn't find out it closed until after I moved here (partly to be close to it) :/. Perceived cost of living keeps me from moving to a different metro area with better services.
Since the pattern is increasing all around, more social support structures are emerging around work-from-home lifestyles, but frankly, the current state is very primitive.