> I think the George Box aphorism linked at the bottom ("All models are wrong [but some are useful]") is closer to the right way to think about this.

Also, see the original article:

> Bonini's Paradox, named after Stanford business professor Charles Bonini, explains the difficulty in constructing models or simulations that fully capture the workings of complex systems (such as the human brain).

A model is "too complex" by this definition if there can be no complete and accurate virtual representation of it, it can't be wrong by definition. If you emulate a CHIP-8, for instance, you are able to accurately represent the full state of the system inside the emulator; therefore, the emulator is capable of full accuracy. It's impossible to do the same with a human brain, as quoted in the article.