Absolutely. Corman Common Lisp was a great example of this. The REPL compiled to efficient x86 machine code.
http://www.jlhub.com/julia/manual/en/function/code_native
It's basically a Lisp with syntax, being bootstrapped with femtolisp for its Lisp-like macro system.
https://docs.julialang.org/en/v1/manual/metaprogramming/inde...
Absolutely. Corman Common Lisp was a great example of this. The REPL compiled to efficient x86 machine code.