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A few of interest to me:

1. Is steelmanned buddhism wrong in important ways? Can some sort of minimal set of claims version of buddhism even be steelmanned consistently?

2. The joint-stock corporation appears to be the most scalable coordination tech ever invented. What is the embedding space of the things that make it possible and what else is in the space?

3. Does most progress come from pairs of people in high bandwidth collaboration? How could we test this and how could we scale the matching problem implied? If this is true why aren't there more famously successful twins? (also mentioned by Gwern)

4. Are dramatically better matching algorithms possible (lemon markets, costly signal bandwidth saturation)? Ones good enough that they would encourage more geographic mobility?

5. What's the natural embedding space of 'values'? If discovered and rendered tractable would this solve problems with our current attempts at formalization (VNM, Arrow's impossibility, various decision theory gotchas etc)?

6. Why are all the general purpose 'how to navigate life' resources so poor in quality? (also mentioned by Patrick)

7. Does DNA (and RNA?) transcription error rate emerge as a natural kind in large scale biological prediction? Does this create natural limits on malleability of biological systems?

8. Is there low hanging fruit in CNS imaging? Would this directly lead to dramatically better mental health interventions?

9. Can research stagnation be undermined by funding more research review enabling more cross collaborative legibility of researchers into each other's work?



Can you say more about the steelmanned buddhism questions? I'm interested but not clear on what you're pointing to with the term "steelmanned buddhism" or what important ways you think it might be wrong about.

Edit: Just to clarify, I'm familiar with the idea of steelmanning, but not what set of buddhist ideas you're pointing to with the term "steelmanned buddhism".




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