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There are strong genetic predispositions for LongCovid, most people can’t get it no matter how sick they get or how many times they get it. The fact that you’re in the majority group is not yet statistically significant.


I'm not sure it has been shown that you can't get it at later infections and anecdotally from friends and family (I know) that doesn't seem to be the case.

I'm also not sure if everyone notices changes if they are mild enough. I am fairly sure that a recent cold was COVID (because I infected my wife who lost her sense of taste) and it took me a while to notice my sense of smell is significantly worse. Too early to describe it as long COVID and certainly as annoyances go, this is as mild as it gets (if it is all there is).


More people do get it from multiple infections but it is still a minority and it seems to be the same genetic predispositions. I have hEDS which comes with ME/CFS, probably the best way to explain it is that it feels like burnout that doesn’t go away.

LongCovid has become an overloaded term with multiple PASC and acute organ damage being added. That’s slowly being fixed with PEM being the defining characteristic. Basically if you exercise as hard as you can a normal person can repeat in two days, a LongCovid/ME/CFS person cannot get close.


> There are strong genetic predispositions for LongCovid

Data? There are enough large genetic sample projects, such as 23andMe, that this is testable.


Here's some data that shows the strongest predictor of long covid is whether or not your parents are claiming long covid: https://boriquagato.substack.com/p/social-contagion-is-long-...

It's especially interesting because that predictor is stronger than whether or not anyone involved has ever tested positive for covid.


That link is just awful partisan politics. It’s unfortunate that LongCovid is getting swept up into the culture wars. Obviously genetic predispositions are inherited and will be a strong predictor. There is very little difference between ME/CFS and LC, many of these kids will have inherited ME/CFS but would not have been aware of it until awareness of LC picked up. In addition the vaccine is sufficient to cause LC in those predisposed to it. My pre-existing ME/CFS was made substantially worse due to the vaccine and I have not yet had covid. I do have extremely strong ACE2-AAbs which is a marker for LongCovid.


That is not what that link shows. Couldn't you find a link that at least tries to appear non-biased and doesn't descend into needless partisanship?


You’d think so, but doctors seem to be crazy bad at statistics which is astounding since it’s so important to what they do. But its easy to look at the instance of hypermobility and hEDS among LongCovid populations. They occur at rates of 40% to 30% in LC populations and they’re supposed to be rare conditions of 2% to 0.2%. The fact that something so basic and obvious could be repeatedly overlooked should give you and indication on what I think about doctors and medical researchers.




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