> This systematic review was registered in PROSPERO before data collection to preclude data-driven analyses and selective reporting (CRD42020185566). In addition, the methods, including the selection criteria, the statistical analysis, outcomes, and subgroup and sensitivity analyses, were published in advance in a study protocol (Schöttker et al., 2021).

EDIT: And in the protocol, the first subgroup analysis they list is relevant:

> Daily dose versus weekly/monthly bolus dose versus bolus dose at the beginning of the trial followed by a daily dose https://bmjopen.bmj.com/content/11/1/e041607