One trick that really helped with the edit-compile-debug cycle, especially on iOS, was to run the app from the command line instead of using Titanium Studio. I set up a Rake task that would run the app and then listen for a timestamp change to tmp/restart.txt, at which point it would restart the app within seconds. I already had a vim command for touching that file (it's used by Passenger for a similar purpose) so all I do while developing is press a key combination and wait for the simulator to pop back up. Very fast.