I'd take a few hundred over a few. My concern, as another commenter suggested, is mostly around radical changes without any longevity in testing or understanding. Even though a lot of our "natural" foods were created via artificial selection, it's a process that happened over many generations. When it comes to food and nutrition, my gut tells me to generally prefer slow over fast.

Personally I also think there is a big difference between selective breeding, and distilling foods into constituent parts in order to recombine in various ways. Maybe I'm overly paranoid, but I don't fully trust humans to understand and play that part of nature just yet.