There's also a genie out of the bottle problem. Once you decriminalize drugs and people start using them it's very hard to flip a switch and make them stop. To get the data could very well require a massive sacrifice if it turns out to be a very bad idea
Possibly. On the other hand - all drugs started out decriminalised and the reasons for the criminalisation were not always or even usually out of concern for the well being of the user, but racism against the chinese (opium) and black people (marijuana)