Does anyone remember that one weird block script that people post to HN sometimes? The only thing I remember is that it's the kind of thing that would take a good while to learn to read—maybe the blocks for the letters in a word could be recognised as a single shape when juxtaposed?
The only one I remember is Flea's Knees, which uses specific colors for each pixel and depends on the RGB layout of LCD subpixels to effectively triple the horizontal resolution. The letters are 4 pixels wide and relatively very tall.