Yes. There are long standing feature requests for (e.g.) the reflect package that simply don't get done because they'd break this assumption and/or force further indirection in hot paths to support "no code generation at runtime, ever".
Packages like Yaegi (that offers an interpreted Go REPL) have "know limitations, won't be addressed" also because of these assumptions.
It has the limitations mentioned, which are necessary to make duck-typed interface calls reasonably efficient, if you assume no code generation at runtime, ever.
There's really no other way. If you don't know before hand all the interfaces that might exist, and/or all the types that might implement them, interface method calls would necessarily either need to be JIT generated, or a string based hash map lookup (runtime reflection, which exists, but is slow).
Go avoids both by knowing statically at compile time the list of all interface and the list of all types that can ever possibly implement them and building vtables for those.
You can bet the Go compiler and runtime leverage that assumption.