How much do you believe that the MoA actually matches what is happening in the underlying reality of a disease and its treatment?
Vioxx is a nice example of a molecule that got all the way to large-scale deployment before being taken off the market for side effects that were known. Only a decade before that, I saw a very proud pharma scientist explaining their "mechanism of action" for vioxx, which was completely wrong.
Vioxx is a nice example of a molecule that got all the way to large-scale deployment before being taken off the market for side effects that were known. Only a decade before that, I saw a very proud pharma scientist explaining their "mechanism of action" for vioxx, which was completely wrong.