If a trackpoint was not available, I would prefer the following layout:

1) Keyboard with the number pad moved to the left and an integrated trackpad on the right side (centered slightly above home row).

OR (w/out integrated trackpad)

2) [For right handed folks] Keyboard with number pad on left and mouse on right.

The goal being to minimize the distance moving your fingers to the 'mouse zone' while still remaining on home row. The number pad on the right (for right handers) takes up too much space.