> negative long-term consequences? - It’s great to hear about the positive consequences of this, but since it appears you have to take the drug long-term, what are the negative consequences to doing so?
The GLP drugs very commonly cause GI issues. It isn’t clear yet if those effects can be permanent but they do remain at least for a while after stopping treatment.
Yes muscle loss is common due to rapid weight loss, usually without compensation like strength training. The effect of the drug is in reducing appetite so it is literally equivalent to calorie restriction, not some sort of fat targeting drug. But I think the public assumes it will create the “right” weight loss. Unfortunately older drug users won’t be able to regain that muscle mass easily.
The GLP drugs very commonly cause GI issues. It isn’t clear yet if those effects can be permanent but they do remain at least for a while after stopping treatment.