I've actually used it for almost a year, as a primary browser. One of the reasons was that it allows (allowed?) switching of font rendering engine to either Apple or Microsoft one. It was part of the experiment whether it's possible to live with a Mac with its extremely blurry though shape-preserving rendering.
Turns out they've bet on ultrahigh resolution displays, where their rendering is perfect.
The other way to go (which I've noticed most Mac people do go with) is comparatively larger fonts. As long as you are above 12px, the Apple font rendering not only looks nicer, but I seem to be able to read it faster.
Of course, I want 12px or smaller unless a display is really high DPI... ;-)
Have you ever considered using GDIPP or Mactype? I used both, GDIPP doesn't work with Chrome so i switched to Mactype a few months back. Everything looks great, but in some situations, certain letters don't show up (like the lowercase "l") which happens very rarely.
Turns out they've bet on ultrahigh resolution displays, where their rendering is perfect.