This is within the larger story of Homo Sapiens. Because CYP21A2 variants are much older and come from the primate tree there would have been continuous and separate adaptations on each branch. Homo Erectus improved language today and is associated with better estrogen signaling while Neanderthals went down the immune system and grain path. Denisovan which did interbreed with Neanderthals reporting the same rs6467 variant might have pursued another branch of selection pressure such as TAAR, and I highly suspect, but have not confirmed, kept or selected for longer AR promoter reducing AR signaling. The most famous of all is Denisovan introducing a Zinc deficiency variant which is such a good adaptation it is found in all non-african humans and notably can reduce ER signaling directly via BHMT. The combination of each adaptation increases the fecundity of atypical HPA axis individuals and the associated intelligence.

Because humans can develop a zona reticularis in their adrenals (unlike marmoset which has partially solved this with an adaptation) the way HPA axis variants interact with steroidogenesis influences sexual differentiation and reproduction in homo sapiens there is constant push and pull.