I used kinesis advantage for 15 years, switched to a glove80 for the past 2, but recently went back to kinesis with an advantage2. The glove80 is very nice, but my hands are big enough that the kinesis thumb cluster works better for me and the cherry mx brown switches are much more satisfying than the low profile chocs.

So ymmv, but for those with larger hands, it may make sense to try a kinesis.