I'm not sure what a typical ketamine dosage looks like, but I have discussed it with my psychiatrist as a fallback if TMS doesn't work out, and she said that ego death is one of the primary mechanisms (alongside reintegration therapy, spending a weekend tripping balls won't fix a thing - at least perpetually).
For humans the antidepressant dose is very low - I think less than 50mg. You might feel some minor dissociative effects at that dose, but only minor, yet in some patients it can apparently produce a pronounced antidepressant effect which is interesting and suggests a non NMDA mechanism
