These folks gave an interesting talk on producing pharmaceuticals at defcon a couple years ago.

IIRC it was more about production methods than developing new treatments.

https://fourthievesvinegar.org/

This made me think of the "Institute for one world health" . It came out as a non-profit pharmaceutical company in the mid 2000's. Victoria Hale was the founder-it got her a MacArthur fellowship. It is focuses(focused?) on global health and populations underserved by for-profit models. I think they successfully developed a treatment for leishmaniasis. it's an adorable model and should be pushed but as usual it seems like the philantropy money is limiting.