I could really go for a sane caching load balancer. My experience with stuff like pound,squid and nginx so far leaves much to be desired (and chaining them isn't exactly desirable either).
Why do they have default maximum url lengths less than IE that can only be fixed with a recompile, its madness I tell you :p
Travis, yeah my impression is similar -- a reverse proxy cache (e.g., Squid or Varnish) plus a light weight layer 7 load balancer (which is how I tend to use nginx)
