Bioshock was the first to make me uncomfortable with a choice. Do I harvest the Little Sister, and get more powerful? Or do I "rescue her", which itself looks a bit like torture at first, and send her off in a place that is filled with psychopaths who'd want to kill her anyway.
Later in the series, when I experienced what it's like to BE a Little Sister, it almost made me regret "rescuing them" before, because the way they see the world as a Little Sister is quite beautiful, and they did serve a profound purpose.
The final choice seems to be a moral absolute, but it was a deeply unsettling choice, for me, to make, and to revisit again later.
It's not really a choice, because in the end you get more powerful by not harvesting the Little Sisters. The only reason to do it is to see the evil ending cut scene.
I'm amused by the joke, but I don't consider it a spoiler to explain how one bad act ever leads to the uber-evil ending that has no connection to the rest of the game. It's just pointing out that the claimed 'moral choices with consequences' feature is a farce.
Later in the series, when I experienced what it's like to BE a Little Sister, it almost made me regret "rescuing them" before, because the way they see the world as a Little Sister is quite beautiful, and they did serve a profound purpose.
The final choice seems to be a moral absolute, but it was a deeply unsettling choice, for me, to make, and to revisit again later.